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KMID : 0043319900130020121
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Archives of Pharmacal Research
1990 Volume.13 No. 2 p.121 ~ p.125
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Protective Effect of Copper against Pancreatic Insult in Streptozotocin-induced Diabetogneic Rat
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Kim HC
Jhoo WK/Kim KH/Kim JT/Lee SJ/Hur IH
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Abstract
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The present study examined the alterations in endogenous oxy-radical scavenging system of pancreatic tissue associated with the dose of 45mg/kg streptozotocin (STZ) alone or with various combinations. The activities of pancreatic Mn-superoxide dismutase (SOD) and catalase were no apparent changes in the other groups except for the Cu(II) 4mg/kg pretreated group. The presence of 4mg/kg of Cu(II) with or without 125mg/kg of diethylenetriaminepentaacetic acid (DTPA) markedly attenuated the fall in activity of Cu, ZN-SOD by STZ stress. In particular, STZ-induced superoxide generation was dramatically abolished by prior administration of Cu(II) 4mg/kg. Conclusively, We suggest the possible involvement that copper may enhance the defense mechanism of pancreatic oxidative damage by STZ challenge.
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KEYWORD
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